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Moreover, TNF- can promote glycolysis through the activation of the NF-B signaling pathway, supporting rapid tumor cell proliferation by inducing metabolic reprogramming in the tumor microenvironment [234, 237] and thereby enhancing the adaptive growth and metastatic capabilities of tumor cells

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[20] While the overall energy expenditure remained consistent across meals, the scientists found that the meals heavier in fats, as expected, increased fat oxidation

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